Human Papillomavirus 11 Early Protein E6 Activates Autophagy by Repressing AKT/mTOR and Erk/mTOR
Identifieur interne : 000771 ( Main/Exploration ); précédent : 000770; suivant : 000772Human Papillomavirus 11 Early Protein E6 Activates Autophagy by Repressing AKT/mTOR and Erk/mTOR
Auteurs : Boya Zhang [République populaire de Chine] ; Yinjing Song [République populaire de Chine] ; Siyuan Sun [République populaire de Chine] ; Rui Han [République populaire de Chine] ; Chunting Hua [République populaire de Chine] ; Stijn Van Der Veen [République populaire de Chine] ; Hao Cheng [République populaire de Chine]Source :
- Journal of Virology [ 0022-538X ] ; 2019.
Abstract
We transfected an HPV11 E6 plasmid into HaCaT cells, H8 cells, and NHEK cells and established a stable cell line expressing the HPV11 E6 protein. Then, we confirmed that HPV11 E6 induces autophagy by suppressing the AKT/mTOR and Erk/mTOR pathways. In contrast to the high-risk HPV E6 genes, HPV11 E6 did not affect the expression of p53. To the best of our knowledge, this study represents the first direct in-depth investigation of the relationship between the LR-HPV E6 gene and autophagy, which may help to reveal the pathogenesis of LR-HPV infection.
Url:
DOI: 10.1128/JVI.00172-19
PubMed: 30971468
PubMed Central: 6613752
Affiliations:
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Yinjing" uniqKey="Song Y" first="Yinjing" last="Song">Yinjing Song</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Sun, Siyuan" sort="Sun, Siyuan" uniqKey="Sun S" first="Siyuan" last="Sun">Siyuan Sun</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Han, Rui" sort="Han, Rui" uniqKey="Han R" first="Rui" last="Han">Rui Han</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Hua, Chunting" sort="Hua, Chunting" uniqKey="Hua C" first="Chunting" last="Hua">Chunting Hua</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Van Der Veen, Stijn" sort="Van Der Veen, Stijn" uniqKey="Van Der Veen S" first="Stijn" last="Van Der Veen">Stijn Van Der Veen</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Microbiology and Parasitology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology and Parasitology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Cheng, Hao" sort="Cheng, Hao" uniqKey="Cheng H" first="Hao" last="Cheng">Hao Cheng</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We transfected an HPV11 E6 plasmid into HaCaT cells, H8 cells, and NHEK cells and established a stable cell line expressing the HPV11 E6 protein. Then, we confirmed that HPV11 E6 induces autophagy by suppressing the AKT/mTOR and Erk/mTOR pathways. In contrast to the high-risk HPV E6 genes, HPV11 E6 did not affect the expression of p53. To the best of our knowledge, this study represents the first direct in-depth investigation of the relationship between the LR-HPV E6 gene and autophagy, which may help to reveal the pathogenesis of LR-HPV infection.</p></div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Zhang, Boya" sort="Zhang, Boya" uniqKey="Zhang B" first="Boya" last="Zhang">Boya Zhang</name></region><name sortKey="Cheng, Hao" sort="Cheng, Hao" uniqKey="Cheng H" first="Hao" last="Cheng">Hao Cheng</name><name sortKey="Han, Rui" sort="Han, Rui" uniqKey="Han R" first="Rui" last="Han">Rui Han</name><name sortKey="Hua, Chunting" sort="Hua, Chunting" uniqKey="Hua C" first="Chunting" last="Hua">Chunting Hua</name><name sortKey="Song, Yinjing" sort="Song, Yinjing" uniqKey="Song Y" first="Yinjing" last="Song">Yinjing Song</name><name sortKey="Sun, Siyuan" sort="Sun, Siyuan" uniqKey="Sun S" first="Siyuan" last="Sun">Siyuan Sun</name><name sortKey="Van Der Veen, Stijn" sort="Van Der Veen, Stijn" uniqKey="Van Der Veen S" first="Stijn" last="Van Der Veen">Stijn Van Der Veen</name><name sortKey="Van Der Veen, Stijn" sort="Van Der Veen, Stijn" uniqKey="Van Der Veen S" first="Stijn" last="Van Der Veen">Stijn Van Der Veen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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